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Incubations using HepaRG cells Cell incubations were performed in a monolayer assay (Kroesen et al

Malignant cells can also hijack the macrophage erythrophagocytosis process

Higher levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) were found to be present, which is a marker for oxidative DNA damage, and when melatonin was introduced, there was an appreciable decrease in the levels of 8-OHdG, which shows that melatonin is a protective factor against ROS-induced DNA injuries (189)