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Paradoxically, the ROS-limiting capabilities of p53 have also been implicated in facilitating tumor growth by suppressing excessive oxidative stress, which could cause cancer cell death (Humpton And Vousden 2016)

In the NADPH monooxygenase system: P450 oxidoreductase transfer the electrons from NADPH to P450 and results in the formation of ferrocytochrome P450 which carried out molecular oxygen activation and one of the atoms of oxygen is added to the substrate molecule (Riddick et al., 2013)