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This study demonstrated that different analogs have variable abilities to bind HGF, and that the analogs showing antagonism to HGF are acting as a Hinge mimics D-Nle-X-Ile-NH(CH 2 ) 5 CONH 2 derivatives were found to compete with Hinge for HGF binding and exhibited a range of affinities for HGF, with K i s ranging from 1.3710 7 -1.3310 10 M ( 26 , 27 )

R2 is an amino acid selected from the group selected from the group consisting of tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine and valine

That is why medical supervision matters before considering any peptide-related option