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doi: 10.1016/j.bbrc.2005.03.012

No disease has been attributed to the loss of PrP expression in humans 16 and loss of one functional PRNP allele is compatible with life 17

Moreover, total and differential BALF cell counts for neutrophils, macrophages and lymphocytes were found elevated in LLC-challenged Igf1r fl/fl mice, while this increase was less pronounced in CreERT2 mice