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Mitochondria are not only a source of ATP energy, but also generators of ROS, which can both regulate physiological processes, such as the transition from hyperplastic growth to hypertrophic growth after birth, and cause oxidative damage

A prospective cohort study with Helicobacter pylori-infected patients shows that 33% of the patients treated with omeprazole for 5 years developed an atrophic gastritis with a significant decline of serum vitamin B12 levels (T0: 340 T1: 280pmol/L, p 1year) with omeprazole

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