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These cells are also specialized to recognize bacterial-derived molecules, known as prokaryotic-associated molecular patterns, with the help of the Toll-like receptors on the cell surface and the nucleotide-binding oligomerization domain-like receptors in the cytoplasm, which activate defense mechanisms by the secretion of anti-microbial peptides 2

Effect of Dangfei Liganning capsule on liver X receptor /steroid regulatory element binding protein-1/fatty acid synthase signal pathway in rats with metabolic-associated fatty liver disease

To increase the working sample volume, the gold nanoparticle solution was diluted 1:2 in deionized water

Furthermore, besides the aforementioned methods directly targeting ferroptosis and associated pathways, restraining iron uptake also represents a putative therapeutic approach for NAFLD, as the activity of iron uptake in the gut was much higher in NAFLD/NASH patients (146)