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Rizzoli SO, Jahn R

This glutamate is then further catalyzed to -ketoglutarate via deamination mediated by glutamate dehydrogenase (GLUD1) or transamination mediated by transaminases [331]

Although technical challenges precluded our immuno-EM verification of intermediate filament identity, the structures we documented in mCherry-expressing ALM neurons are strikingly reminiscent of maturing mammalian aggresomes that form under high proteostress and are characterized by intermediate filament proteins that coalesce around sequestered aggregated protein 3,5,24,25 , consistent with our florescence microscopy visualization of tagged IFD proteins in proteo-stressed neurons