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He X, Wang Z, Ge Q, Sun S, Li R, Wang B

Prof Ranjan K Singh is thankful to DST- FIST programme, and ongoing BHU IOE scheme for financial support

A 2023 meta-analysis of these trials concluded that probiotics (usually multi-strain combinations of Lactobacillus and Bifidobacterium ) led to a significant reduction in pro-inflammatory cytokines (like TNF- and IL-6) and a slight improvement in patients Expanded Disability Status Scale (EDSS) scores [201]

Collectively, this approach was designed to provide a comprehensive, balanced, and mechanistically coherent synthesis of the existing evidence, while acknowledging variability in study quality, extract standardization, and clinical methodology across the literature