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The current body of evidence is predominantly preclinical, limiting the extrapolation of therapeutic claims to clinical practice

If clinical suspicion of cyanide poisoning is high, CYANOKIT should be administered without delay 1 CYANOKIT can be used to treat multiple sources of cyanide poisoning, including smoke inhalation and ingestion 1 Hydroxocobalamin, the active ingredient in CYANOKIT, has been used in France since the 1980s, was formally licensed there in 1996, and was approved in the United States in 2006 to treat known or suspected cyanide poisoning 6,7 Clinical Experience Randomized clinical trials in humans are not possible due to ethical considerations, therefore evidence in controlled trials of the effectiveness of hydroxocobalamin for the treatment of cyanide poisoning was obtained primarily from studies in animals

These are not temporary effects

Therefore, hyperhomocysteinemia-induced depletion of TH may not involve in the development but only in the progression of PD through the degeneration of dopaminergic neurons with secondary deficiency of TH in PD (Kawahata and Fukunaga 2020