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From the paper titled " The basis for folinic acid treatment in neuro-psychiatric disorders " by Ramaekers et al., 2016: On the left side of the figure, the purine metabolite GTP serves as the substrate for the GTP-cyclohydrolase I enzyme (GTPCH) to produce tetrahydrobiopterin (BH4), which is the co- factor for enzymes producing dopamine, serotonin and NO

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On the contrary, the stimuli from the liver influence feeding behavior in the brain, for example, hepatokine has emerged as the essential mediator of the regulatory circuit from the liver to the brain

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Animals 14, 2156

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