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In this scenario, it becomes very attractive to study and explore the endothelium, through which inflammatory cells must transmigrate [transendothelial migration (TEM)] to reach the lung parenchyma and cause damage ultimately leading to COPD onset and progression

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The primary reason is that inhaled hydrogen would directly impact the alveoli, Type I and Type II alveolar cells, and would rapidly diffuse into the pulmonary capillaries