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Additionally, glutathione plays a critical role in detoxification and the removal of free radicals, thereby affecting gsh content and status

It arises from an abnormally expanded CAG trinucleotide repeat encoding the elongated polyglutamine (polyQ) within exon 1 of Huntingtin ( HTT ) gene, which results in the production of toxic mutant huntingtin proteins (mHTT) that accumulate in neurons, particularly in the striatum and cortex ( HTT gene normally contains 10 to 35 CAG trinucleotide repeats, while HD patients exhibit more than 36 repeats

These results evoke the speculation that higher dTTP level in T315I-Bcr-Abl-32D cells might prevent DNA replication stress to affect JMF4073 sensitivity

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