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Cell Comm Signal

The study was also performed in GNE knockdown cells with similar observations

Trx/TrxR is an NADPH-dependent cellular thiol reduction antioxidant system associated with disulfide stress

The following defensive enzymes found to play a key role in the organism protection against glycoxidation: aldo- and keto-reductases, aldehyde and alcohol dehydrogenases, carbonyl reductases, amadoriases (deglycases), cytochromes P450 family, glutathione reductase, glucose-6-phosphate dehydrogenase, glutathione-S-transferases and glutathione-dependent glyoxalase system (2, 14, 133, 134)