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Betaine serves as a methyl donor in the conversion of homocysteine to methionine, contributing to one-carbon metabolism and methylation reactions

OATP isoforms such as OATP1B1, OATP1B3, OATP1A2, and OATP2B1 are particularly relevant to BBB transport, influencing CNS drug permeability and offering potential targets for enhancing drug delivery to the brain [104,105]

Free Radic Res 52(2):198211

David Rosmarin, a dermatologist at Tufts Medical Center and lead investigator of the clinical trial of the therapy, said roughly half of the patients who develop vitiligo see symptoms by the age of 20