l-carnitine transport fatty acids mitochondria Carnitine Shuttle - an overview Carnitine: Genetic Variants Affecting Mitochondrial

We observe several folds reduction in the expression of all the plasma membrane biogenesis genes ( pgsA1 , pgsA2 , which is a putative cardiolipin synthase gene, and pgsA3 ) in the knock-out strain as compared to the wild-type and the complemented strain (Figure 3E)

W.VichaiV.PearsonW

The assessment of plasma TMAO profiles after the exposure to a precursor, such as in an OCC, is essential to capture the effect of the polyphenols on the magnitude and timing of TMAO exposure rather than fasting TMAO concentrations alone

Response: We thank the commenters for their suggestions for additional stratifications for public reporting of the measure