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Clinically, it is characterized by resting tremor, bradykinesia, muscle rigidity, and postural instability [1]

First-in-human clinical trials, also known as FIH trials, are studies during which a drug is administered to humans for the first time after its testing in in vitro and in vivo preclinical, experimental models

As the expression of CutC/D enzymes has been demonstrated in 100% of all people examined, while between 6 and 21% of people are estimated to lack the betaine metabolising grdH enzymes, it is possible faecal samples from participants involved in our study lacked the grdH enzymes [31, 32]

doi: 10.1016/j.celrep.2016.09.045