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Despite its evident involvement in kidney fibrosis, to date, no therapeutic strategies targeting the Shh pathway have been approved for the treatment of kidney injury

Although it was previously assumed that a higher number of hydroxyl groups might decrease reactivity due to steric hindrance, more recent evidence suggests that additional hydroxyl groups can enhance redox potential, particularly in the absence of aggregation or spatial obstruction (Hwang et al., 2015)

Slater, Michael W., Xochitl Vinaja, Islam Aly, Marios Loukas, Mark Terrell, and Justine Schober