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In response to oxidative stress, NRF2 dissociates from KEAP1, translocates to the nucleus, and activates genes encoding antioxidant enzymes (e.g., superoxide dismutase SOD) and glutathione synthesis enzymes, reducing reactive oxygen species (ROS) and mitigating oxidative damage ( Therapeutic interventions targeting redox imbalance in fibromyalgia Currently, there is a lack of randomized controlled trials (RCTs) directly evaluating redox-modulating interventions targeting the central nervous system (CNS) in fibromyalgia

In patients with acute heart failure, TMAO was found to be associated with in-hospital mortality and poor prognosis at 1 year

Jain S, Kumar K, Malhotra S, Sibal A BMJ case reports 2022

Alternate-day fasting alleviates high fat diet induced non-alcoholic fatty liver disease through controlling PPAR/Fgf21 signaling