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Additionally, side effects include diarrhea, mild fever, trouble sleeping, headaches, and pain, itching, or swelling at the injection site

As mentioned previously, the widespread and prolonged use of histamine H 2 -receptor blockers and proton pump inhibitors for ulcer disease also may cause impaired breakdown of vitamin B 12 from food, causing malabsorption and eventual depletion of B 12 stores

Due to the complexity, and size limitations associated with the cobalamins, the primary method for calculating ground state properties is density functional theory (DFT), while time-dependent DFT (TD-DFT) is used for electronically excited states