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The researchers used Annexin-V FACS analysis and DNA laddering to demonstrate that Sag activated apoptosis in the sensitive cell lines in a dose- and time-dependent manner

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516,517 Knockdown of METTL3 promotes the expression of FSP1 and SLC7A11, whereas METTL3 overexpression aggravates cystine deprivation- and erastin-induced ferroptosis in human aortic smooth muscle cells (HASMCs), suggesting that METTL3 may promote ferroptosis in HASMCs primarily by inhibiting FSP1 and SLC7A11 expression