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6.3 Critical assessment and challenges of SSP-targeted therapy 6.3.1 Target specificity and toxicity evaluation in normal tissues The SSP is not only aberrantly activated in tumor cells but also participates in fundamental metabolism in normal tissues, including the nervous system, immune cells and the liver

Jackson CB, Farzan M, Chen B, Choe H

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The most significant factors affecting individual alcohol metabolism rate are biological sex, body weight, liver health, and genetic ALDH2 and ADH enzyme variants