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While no variants in/near these genes have been associated with hypertension in genome-wide association studies, it is possible that these are associated with salt-sensitive hypertension

By selectively blocking NNMT, 5-Amino-1MQ is investigated for its ability to preserve cellular NAD+ pools, reduce methylation of nicotinamide to inactive 1-methylnicotinamide (1-MNA), and enhance sirtuin activity and energy metabolism