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P.LongS

Since the peak levels after once-daily oral TRT oversuppress the TSH, neither the population TSH reference range nor the patients own premorbid TSH level can be the goal of therapy

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The method is based on the assumption, that the binding of the (pro)drug occurs mainly inside the cells and that estimation of C u,cell indicates the overall unbound drug concentration in the brain intracellular compartment without specifying the distribution to the specific parenchymal cells or subcellular structures