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In the cell-free GCLC enzymatic assay, BSO inhibited the activity of GCLC with an IC50 of 570 nM [95% confidence interval (CI) 429757 nM

Furthermore, elevated concentrations of advanced oxidation protein products (AOPPs) were observed in patients with severe MDD, suggesting a detrimental effect on proteins attributable to chlorinative stress [128]

In vitro cell culture model Cytocompatibility/safety of DNZ-NLP The cytocompatibility effects of DNZ-NLPs (at concentrations of 10, 25, 50, 100, and 200 g/mL) were assessed against SH-SY5Y cells

stable at room temperature for approximately 3 weeks Reconstituted BPC-157: Store at 2 to 8C (refrigerator temperature) and use within 4 weeks Protect from light and avoid repeated freeze-thaw cycles Never use the solution if it appears cloudy or contains particles Side Effects Preclinical animal studies have demonstrated a favorable safety profile for BPC-157, with no acute toxicity observed across multiple organ systems, including liver, spleen, lung, kidney, brain, thymus, prostate, and ovaries at doses ranging from 6 g/kg to 20 mg/kg over 6-week periods