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Wang S, Yi X, Wu Z, Guo S, Dai W, Wang H, et al

5.1.4 MS-based proteomics: targeted proteomics (MRM/SRM) for biomarker validation Targeted proteomics, predominantly utilizing Multiple Reaction Monitoring (MRM) or Selected Reaction Monitoring (SRM) mass spectrometry, represents a hypothesis-driven methodology for precise and sensitive quantification of pre-selected proteins through their representative peptides