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A cleft lip results when the lip tissue doesnt join completely together before birth, leaving an opening in the upper lip anywhere from a small slit to a large hole that extends from the lip into the nose

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Mouse husbandry For the isolation of mitochondria and proximal tubular cells, kidneys were excised from cadavers of 812-week-old male and female wild type C57/BJ and C57/BJ crossed with 129S6 used for other experimental purposes not related to this study, following the principles of the 3Rs (Replacement, Reduction and Refinement) of animal experimentation