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Oxidative stress In the Banting lecture Brownlee referred to overproduction of superoxide (O2 - ) by the mitochondrial electron transport chain as the one element linking the different pathogenic pathways to diabetic complications ( Oxidative stress occurs is a result of an inability of cellular antioxidant mechanisms to neutralize increased generation of reactive oxygen species (ROS) (66)

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Peters SU, Kaufmann WE, Bacino CA, Anderson AW, Adapa P, Chu Z, et al

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