Introduction A marked rise in the global prevalence of obesity and associated metabolic pathologies has been observed over the past 30 years ( Globally, more than 1 billion people are estimated to have NAFLD, including 83 million patients in the United States, making NAFLD the most common chronic liver disease in the US ( NASH is diagnosed histologically, based on the extent of steatosis, hepatocyte stress and damage (hepatocyte ballooning), immune infiltration (lobular inflammation), and degree of fibrosis ( While late-stage NASH greatly increases the risk of liver-related morbidity, NAFLD and NASH with less advanced fibrosis (i.e., F0F2) are associated with greatly increased risk of cardiovascular disease and related mortality ( Despite the unmet medical need, there is currently no approved therapy for NASH
Haematologica (2010) 95:181422
Similarly, neuronal hypersynchrony is observed in models of AD 102,103 and can manifest as clinical or subclinical epilepsy, which can occur during the early stages of AD 104,105,106,107,108,109,110
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