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Diaz-Ruiz A, Salgado-Ceballos H, Montes S, Maldonado V, Tristan L, Alcaraz-Zubeldia M, et al

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ROS can directly activate the NF-kB transcription factor pathway, promoting the synthesis of inflammatory cytokines (85)

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Intestinal dynamics and adaptability Intestinal adaptability is crucial for responding to substantial nutritional stress and associated metabolic processes due to diminished absorptive surface, while also being vital to appropriate physiological responses to continuous environmental and dietary stresses

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TME limitations Copper-targeted therapy is significantly limited by the TME

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