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In a hypoxic environment, the activity of PHD2 in osteocytes is reduced and HIF signalling is enhanced, improving the activity of the canonical Wnt signalling pathway through the HIF-SIRT1-SOST--catenin signalling axis, thereby promoting bone formation mediated by the activated Wnt/-catenin signalling pathway and inhibiting osteoclast bone resorption mediated by RANKL and OGP

Further exploration into quercetins therapeutic potential, within the context of TCM and beyond, could pave the way for novel interventions in liver fibrosis management, emphasizing the importance of early detection and treatment in curtailing the adverse outcomes associated with this condition