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Surgical interventions represented the largest proportion at 30% (28 studies), with a strong emphasis on minimally invasive techniques such as endoscopic discectomy (NCT06615518) and disc replacement procedures (NCT06989632)

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Another study showed that benfotiamine prevents stress-impaired adult hippocampal neurogenesis, as well as stress-induced bodyweight loss, anxiety-like behavior and oxidative stress in mice [75]

Some patients find that taking their supplement with the largest meal of the day provides optimal tolerance