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In the cytoplasm, one molecule of glucose can be converted to two molecules of pyruvate via glycolysis that involves a reaction catalysed by 10 enzymes, during which a small amount of ATP and the electron carrier NADH are generated, and pyruvate then enters the mitochondrial matrix and is oxidated by the pyruvate dehydrogenase system to acetyl-coenzyme A (Acetyl-CoA), which generates NADH through the eight steps of the Krebs cycle and participates in the functioning of the ETC, producing ATP and supplying energy for cellular activities ( 3.4 Hypoxaemia Hypoxia is a feature of the synovium in RA

Among them, specifically targeting the downstream mediators of c-Met involved in tumor progression is a promising method, including the Grb2 SH2 domain, Src, MAPK, STAT3, Shp2 (Liu et al., 2018), and Fak (Jo et al., 2015)

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