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While the majority of the Rossmann and globin binding domains are relatively unperturbed, the N-terminal four helix bundle adapts to the removal of the adenosine through changes in the position of the Glu71/His72 containing helix

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Additionally, radiation-induced damage is amplified by the generation of reactive oxygen species (ROS), chemically reactive entities capable of oxidizing proteins and lipids and inducing single-strand DNA breaks (indirect effects)