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Sharma D, Chaubey P, Suvarna V

PTX has been used alone and in combination with vitamin E (alpha-tocopherol) in preclinical and clinical studies to reduce long-term effects of radiation such as fibrosis [215217]

Associations of genetic polymorphisms of the transporters organic cation transporter 2 (OCT2), multidrug and toxin extrusion 1 (MATE1), and ATP-binding cassette subfamily C member 2 (ABCC2) with platinum-based chemotherapy response and toxicity in non-sma

Elevated plasma iron levels, in turn, lead to an increase in iron transport into parenchymal cells, particularly hepatocytes, pancreatic cells, and cardiomyocytes, leading to organ iron overload