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Future research should focus on drug development, combination strategies, mechanistic studies, and biomarker discovery

For example, the administration of erinacine A, C, and S, as well as those of HEM/HEME, reduced the abundance of pro-inflammatory cytokines such as IL-6, TNF-, and IL-1 ( in vivo treatment of HEM containing 5 mg/g of erinacine A inhibited the induced protein expression of cortical and hippocampal iNOS in response to LPS-induced neuroinflammation ( in vivo ( in vitro ( Both erinacines and H