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10.1039/d1fo02676c 31 FangC.ZhangZ.XuH.LiuY.WangX.YuanL.et al (2022)

Cystathionine beta-synthase deficiency is a rare autosomal recessive disorder

In the absence of exogenously supplied vitamin B12, MetE will be the only transmethylase of methionine biosynthesis, making metE an essential gene for methionine biosynthesis ( Since the MetE protein is ubiquitous among bacteria, as it has a pivotal part in the methionine metabolic pathway, to select mAbs recognizing the specific region of Mtb MetE, we produced both the full-length recombinant MetE and its N-terminal fragment, whose sequence is more conserved among mycobacteria

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