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Study design In this prospective cross-over study, five female and five male NZW rabbits each received four treatments with buprenorphine (Vetergesic vet, 0.3 mg/mL, Orion Pharma, Danderyd, Sweden), with 2-week wash-out periods between treatments

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The bovine and human models (1GP1 and 2F8A respectively) were chosen for this study given their mammalian origin and amino acid sequence similarity (87.4%)

Anakinra, a kind of IL-1 receptor antagonist that blocks activity of both IL-1 and IL-1, has been approved by the FDA and the EDA (European Drug Administration) for the treatment of rheumatoid arthritis, systemic-onset juvenile idiopathic arthritis, and familial Mediterranean fever (, , )