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TB-500 is a synthetic analog of Thymosin Beta 4, a naturally occurring peptide found in nearly every cell, with the highest concentrations in blood platelets and wound healing fluid

Key distinctions from growth hormone include [5] : Peptide lacks growth hormone receptor binding domains (specifically binding site 2) Binding site 2 is required for receptor dimerization and activation Competitive binding assays showed AOD9604 cannot compete with hGH for receptor binding Does not function as a growth hormone receptor antagonist Glucose Metabolism Preservation Unlike full hGH, which can induce insulin resistance and hyperglycemia, AOD9604 demonstrates no adverse effects on carbohydrate metabolism

PMCID: PMC2756674

In this condition, people may have symptoms of adrenal insufficiency, such as fatigue, weight loss, low blood pressure and nausea