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CNT, N = 26) were compared using Cohens d as effect size (assuming d 0.80 as large effect)

Once TGR5 is activated in muscles or brown adipose tissue, it stimulates energy consumption, and in the intestine, it increases the secretion of GLP-1 (Fig

In brief, 5 10 A375R cells were plated in High-Content Imaging Glass Bottom 24-well Microplates for 24 h and then treated with either 3 M R4VPL3-1 for 2.5 h or 100 M Cumene hydroperoxide for 2 h (positive control, an established lipid-peroxidation inducer)