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Previous studies indicate that while ATRA upregulates HIV mRNA transcription in infected human HL-60 cell lines, it does not increase viral replication due to blocked HIV mRNA translation and replication

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For this purpose, we will summarize: 1) The current evidence that acutely-induced oxidative stress is cholestatic, by describing the mechanisms underlying the hepatocyte secretory failure, including the disorganization of the actin cytoskeleton and its most noticeable consequences, the impairment of tight-junctional structures and the endocytic internalization of canalicular transporters relevant to bile formation