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Conclusion and outlook The main pathological feature of RF is the excessive or disordered deposition of collagen-rich ECM, which leads to progressive damage to renal structure and function

The authors would like to thank the Laboratory of Basic Medical Sciences, Qilu Hospital of Shandong University, for their help with the experiments

Blots were developed using advanced chemiluminescence (ECL) reagents (GE Healthcare, Amersham, UK) and exposed to autoradiography using Hyperfilm (GE Healthcare)

After just one session, you can already see a visible softening of fine lines across the forehead, around the eyes, and through the nasolabial area