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The channel can also be activated by different stimuli including low pH ( 43C) and oxidative stress leading to the perception of pain, and oxidative injury (Yoshida et al., 2006)

It is further reported that APX gene expression is affected by abiotic stresses like salinity, drought, light fluctuations and abcisic acid (ABA) production (Bonifacio et al., 2012

This scenario is more often seen with shave biopsies where atypical nevus with involved margins is identified, and then additional excision with 2 mm margins is performed