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10.1038/s41422-019-0150-y 18 CowellI

Their short lifespan and segmented nucleus set them apart [54]

When the central repressors of ferroptosis, such as glutathione (GSH) and lipid enzyme glutathione peroxidase 4 (GPX4) [103], which participate in peroxide reduction and reduce product toxicity, show insufficient activity, the lipid radicals formed cannot be cleared and continue to generate new oxidative products via chain reaction