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BMC Cardiovasc Disord 25(1):329 Lian J, Xu Y, Shi J, Liu P, Hua Y, Zhang C, Ren T, Su G, Cheng S, Nie Z, Jia T (2024) Acteoside and isoacteoside alleviate renal dysfunction and inflammation in lipopolysaccharide-induced acute kidney injuries through inhibition of NF-kappaB signaling pathway

Another emerging approach involves the use of personalized peptide-based vaccines based on neoantigens to enhance antitumor response

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This not only makes the area appear darker but may also encourage frequent rubbing or scratching, which can increase pigmentation and worsen the shadowed look