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The exact mechanisms behind oligodendrocyte degeneration are not fully understood, but may include mitochondrial disruption due to a cuprizone-induced copper deficit, ferroptosis (Jhelum, 2020), and endoplasmic reticulum stress responses

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When Histamine Symptoms Extend Beyond Food A low-histamine diet may reduce meal-triggered symptoms, but it cannot by itself determine whether the patient has undermethylation, copper overload, pyroluria, mast-cell activation or another biochemical pattern