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NRF2 is regulated through two principal mechanisms: post-translational modifications (PTMs) and epigenetic alterations

Plasma vitamin E was increased in the GSTM1-null group, while glutathione levels were increased in the GSTM1-present group, and blood vitamin C levels were increased in the GSTT1-present genotype, demonstrating the antioxidant impact of the grape juice differed based on the genotype of the participants

Additionally, another group observed that the hearing ability of NRF2-deficient mice was more impaired and the number of hair cells was significantly reduced compared to the wild-type mice [112]

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