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For example, 2D cultures only allow interactions with neighboring cells and the formation of cell-ECM adhesions on the substrate side in the horizontal plane, whereas in 3D culture, cells are capable of forming adhesions on all sides in a dynamic way [239]

Slovak Research and Development Agency (grant No

Regulation of the methylation and expression levels of the BMPR2 gene by SIN3a as a novel therapeutic mechanism in pulmonary arterial hypertension

4) High drug-loading capacity: Although cell-derived biomimetic functional materials have natural activities such as tumor targeting, evasion of immune recognition and activation of antitumor immunity, their inherently low drug-loading capacity limits their application in drug delivery strategies