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Subsequent work by Itoh et al

Additionally, defective de novo NAD + synthesis has also demonstrated to be a contributing factor in the decrease of renal NAD + levels, especially in the context of renal IRI, which causes a reduction in the expression of de novo NAD + biosynthetic enzymes and the accumulation of certain intermediates, such as quinolinate [146, 147]

Astrocytes and amyotrophic lateral sclerosis/motor neuron diseases Motor neurons are damaged by oxidative stress and reactive astrogliosis in ALS patients (Rao and Weiss, 2004