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A prospective approach.: Results from the HELIAD study

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The question has been raised regarding which CoQH2-generating mitochondrial enzymes other than DHODH and GPD2 regulate ferroptosis 19,20

Potential reasoning for the data lies in earlier studies in colon cancer showing differential effects of CBS and CSE ( 2 S may contribute to tumor growth through activation of PI3K/Akt pathway, inhibition of phosphatases or by regulating expression of cell cycle genes ( 2 S production and higher Akt phosphorylation in rSCC-61 are consistent with these findings