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(A) Partial purification and immunological identification of GliT

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Studies have shown that human immunodeficiency virus 1 (HIV-1)-infected leukocytes not only secrete matrix metalloproteinases (MMP)-2 and MMP-9 that impair the BBB, but also promote immune cell infiltration into the central nervous system via chemokine C-C motif ligand 2 (CCL2) ( + T cells were shown to cross the BBB and induce central nervous system inflammation through activating microglial activation, indicating that immune cell invasion may participate in NPP development following pre-infection ( Figure 2 )